In September 1940, fearing the internment of German Jewish refugee scientists - even possibly those with recent American citizenship - was bound to follow the panicky British Empire decision to most of its German refugees from Hitler, biochemist Dr Karl Meyer became the first leader of what was to become the four year long Manhattan penicillin Project.
Dr Meyer was determined to find some sort of way to prove to the American war machine that he was too valuable to intern.
And finally purifying a drug that could kill the few militarily important pathogen bacteria that the hot new Sulfa drugs could not, would do just that.
Purifying a natural substance is sometimes by far the most difficult step on the road to then synthetizing and patenting it.
Any clinical testing could wait until the substance was safely purified.
For now, what Meyer and his assistant Eleanor Chaffee needed most from their two microbiologists (doctors Dawson and Hobby) was their highly practised skills in growing microbes.
And then later, their other well honed skill in measuring the bacteria-killing powers of any substances Meyer's chemical skills threw up.
But all that changed in early October 1940, when new patient A. (Leroy) Alston heard of the project and in a very real sense, hijacked the leadership of the project.